TARDBP and proteostasis deficiencies: Although recent reports do not support the involvement of stress granules in TDP-43 proteinopathy, or suggest that TDP-43 association with stress granules may in fact be protective (McGurk et al., 2018; Gasset-Rosa et al., 2019; Mann et al., 2019), loss of function studies for the stress granule assembly factor G3BP1 revealed that stress granules facilitate but are not required for TDP-43 aggregation (Fernandes et al., 2020).