TARDBP and proteostasis deficiencies: Subsequent reports that TDP-43 co-migrates with non-ribosomal fractions and polyribosomes in Drosophila models of TDP-43 proteinopathy lend support to the notion that TDP-43 also associates with the translation machinery in vivo and may play a pivotal role in the dysregulation of translation in disease (Coyne et al., 2015).