The in vitro rescue of neurons from excitotoxic death by restoration of the TrkB-FL/TrkB-T1 balance suggests that dysregulation of TrkB isoform expression may be one of the causes leading to neuronal cell-death during stroke (Vidaurre et al., 2012; Tejeda and Diaz-Guerra, 2017). Here, NTRK2 is linked to stroke disorder.