This study stems from the observation that TrkB.T1 is the predominant TrkB isoform expressed across a range of human gliomas and, surprisingly, that high transcript expression of TrkB.FL is associated with better, not worse, prognosis for both glioblastoma multiforme (GBM) and low grade gliomas (LGG; Pattwell et al., 2020). Here, NTRK2 is linked to central nervous system cancer.