Diverse and region-specific dysregulation of BDNF-TrkB signaling has been observed in many neuropsychiatric disorders such as Alzheimer’s disease (AD), Parkinson’s disease, Amyotrophic Lateral Sclerosis (ALS), Huntington’s disease, epilepsy, stroke, mood disorders and schizophrenia. This evidence concerns the gene BDNF and Alzheimer disease.