FMR1 and autism: In addition, a large number of previous studies on ASD led to the compilation of ASD-risk gene sets, including SFARI genes (all genes and high-confidence category 1 genes) (Abrahams et al., 2013)1, FMRP targets (Darnell et al., 2011; Werling et al., 2016), De Novo Missense (protein-disrupting or missense rare de novo variants) (Iossifov et al., 2014; Werling et al., 2016), De Novo Variants (protein-disrupting rare de novo variants) (Iossifov et al., 2014; Werling et al., 2016), and AutismKB (Autism KnowledgeBase) (Xu et al., 2012; Yang et al., 2018; Supplementary Table 5).