Similarly, resolvin E1 (RvE1), a ligand for ERV1 (aka ChemR23, CMKLR1) in myeloid cells inhibited PMN recruitment, stimulated phagocytosis and inhibited production of proinflammatory mediators in murine models of inflammatory and metabolic diseases in part through S6 phosphorylation downstream of the PI3K/Akt and Raf/ERK pathways [36–38]. This evidence concerns the gene AKT1 and metabolic disease.