Similarly, resolvin E1 (RvE1), a ligand for ERV1 (aka ChemR23, CMKLR1) in myeloid cells inhibited PMN recruitment, stimulated phagocytosis and inhibited production of proinflammatory mediators in murine models of inflammatory and metabolic diseases in part through S6 phosphorylation downstream of the PI3K/Akt and Raf/ERK pathways [36–38]. The gene discussed is CMKLR1; the disease is metabolic disease.