Moreover, the T1D autoantigens glutamic acid decarboxylase 65 (GAD65), zinc transporter 8 (ZnT8), and β-cell resident glucose transporter 2 (Glut2) were found within T1D islet EVs (109), supporting both the EV delivery of self-antigen as well as auto-antibody-EV immune complex driven myeloid cell activation via Fc receptors. Here, SLC2A2 is linked to type 1 diabetes mellitus.