When CD24+ MM cells (ARP-1 CD24OE or OCI CD24OE cells) were co-cultured with these CAR-T cells in vitro with the 5:1 proportion of the CAR-T cells and the MM cells, the clearance rates of ARP-1 CD24OE and OCI CD24OE cell lines were 99% and 89%, respectively. The gene discussed is CD24; the disease is Miyoshi myopathy.