Canonical and caspase 1 SGs were upregulated at early time points but decreased at 36 h post-infection whereas exosome SGs and caspase 4 SGs were significantly increased starting from 36 h, suggesting that canonical and caspase 1 secretomes play more roles at early MERS-CoV infection of HMECs whereas caspase 4 and exosome secretomes play more roles in the late and chronic phase infection. The gene discussed is CASP4; the disease is infection.