Of note, the IPA data showed that five pathways promoted by 101 TIGs, namely,TREM1 signaling, role of pattern recognition receptors in recognition of bacteria and viruses, TLR signaling, role of macrophage, fibroblasts and ECs in rheumatoid arthritis, and role of hypercytokinemia/hyperchemokinemia in pathogenesis of influenza. This evidence concerns the gene TREM1 and rheumatoid arthritis.