Moreover, CKD upregulated 4.9% and downregulated 2.0% of canonical secretome, upregulated 1.3% and downregulated 0.7% of caspase 1 secretome, upregulated 2.5% and downregulated 0.8% of caspase 4 secretome, upregulated 3.2% and downregulated 1.5% of exosome secretome, upregulated 8.1% and downregulated 2.7% of WPB secretome, and upregulated 12.5% and downregulated 0% autophagy secretome. This evidence concerns the gene CASP4 and chronic kidney disease.