CD28 and atherosclerosis: Exosome secretomic genes in atherosclerosis had various pathophysiological functions with T cell signaling, namely, oncostatin M signaling, platelet derived growth factor (PDGF) signaling, type-I diabetes signaling (autoimmune), role of NFAT in regulation of immune response (82), cell cycle control of chromosomal replication, type 1 T helper cell (Th1) pathway, systemic lupus erythematosus in B cell signaling, CD28 signaling in T helper cells, neuroinflammation signaling, and PKCθ signaling in T cells.