CASP4 and triple-A syndrome: Among caspase 4 SGs upregulated in atherosclerotic aorta (75 genes), CKD aorta (31 genes), AAA aorta (7 genes), MERS-CoV infected ECs (61 genes) and AVF venous EC reprogramming (11 genes), 4% genes in atherosclerotic aorta were downregulated but no SGs were downregulated in other datasets (LogFC <−1) in NOX2−/− dataset; and 22.67% (atherosclerotic), 19.35% (CKD), 28.57% (AAA), 9.84% (MERS-CoV ECs) and 18.18% SGs (AVF venous ECs) (LogFC >1) were upregulated in NRF2−/− dataset, respectively.