As shown in Figures 2B, C, atherosclerosis upregulated 9.8% and downregulated 5.5% of canonical secretome, upregulated 2.6% and downregulated 0.9% of caspase 1 secretome, upregulated 6.1% and downregulated 1.3% caspase 4 secretome, upregulated 7.8% and downregulated 3.7% of exosome secretome, upregulated 16.2% and downregulated 2.7% of WPB secretome, and upregulated 25% and downregulated 6.2% autophagy secretome. The gene discussed is CASP4; the disease is atherosclerosis.