Exosome SGs in elastase induced AAA aortas had functional pathways, namely, CD28 signaling in T helper cells, interferon signaling, inducible nitric oxide synthase (iNOS) signaling, role of NFAT in regulation of immune response, regulation of IL-2 expression in activated and anergic T cells, Th1 pathway, systemic lupus erythematosus in B cell signaling, role of hypercytokinemia/hyperchemokinemia, T cell receptor signaling, and protein kinase C θ (PKCθ) signaling in T cells. This evidence concerns the gene CD28 and systemic lupus erythematosus.