As shown in Figure 4B, canonical secretomic genes in day 7 AAA aortas had functional pathways, namely, IL-17 signaling, p38 MAPK signaling, cardiac hypertrophy signaling, role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza, TREM1 signaling, HOTAIR pathway, high mobility group box 1 (HMGB1) signaling, dendritic cell maturation, tumor microenvironment pathway, and systemic lupus erythematosus in B cell signaling. The gene discussed is HMGB1; the disease is neoplasm.