Caspase 4-GSDMD secretomic genes in atherosclerosis had various pathophysiological functions with B cell signaling, namely, role of nuclear factor of activated T cells (NFAT) in regulation of immune response, B cell receptor signaling, IL-8 signaling, neuroinflammation signaling, role of protein kinase R (PKR) in interferon induction and antiviral response, Rac signaling, fMLP signaling in neutrophils, Ephrin receptor signaling, endothelin 1 signaling, and systemic lupus erythematosus in B cell signaling. This evidence concerns the gene EIF2AK2 and systemic lupus erythematosus.