Exosome SGs at 6 weeks atherosclerotic aortas had functional pathways, namely, Reelin (a large, secreted glycoprotein for correct neuronal positioning) signaling, EC nitric oxide synthase (eNOS) signaling, cholecystokinin/gastrin-mediated signaling, cardiac hypertrophy signaling, melatonin signaling, calcium signaling, synaptic long-term depression, apelin cardiomyocyte signaling, cardiac hypertrophy signaling and endothelin-1 signaling. Here, EDN1 is linked to cardiac hypertrophy.