In CKD aorta, 14 cytokines/interactors were upregulated in canonical secretome, no cytokines/interactors were upregulated in caspase 1 secretome, one cytokine/interactor was upregulated in caspase 4 secretome, 10 cytokines/interactors were upregulated in exosome secretome, no cytokines/interactors were upregulated in WBP, and two cytokines/interactors were upregulated in autophagy. This evidence concerns the gene CASP4 and chronic kidney disease.