As shown in Figure 3B, canonical SGs in CKD aortas had functional pathways, namely, MIF regulation of innate immunity, triggering receptor expressed on myeloid cells 1 (TREM1) signaling, crosstalk between dendritic cells and natural killer cells, integrin-linked kinase (ILK) signaling, neuroinflammation signaling, cardiac hypertrophy signaling, hepatic fibrosis signaling, role of pattern recognition receptors in recognition of bacteria and viruses, p38 mitogen-activated protein kinase (MARK) signaling, and acute phase response signaling. Here, MIF is linked to chronic kidney disease.