Exosome SGs in AAA aortas had functional pathways, namely, RhoGDI signaling, Signal transducer and activator of transcription 3 (STAT3) pathway, renal carcinoma signaling, senescence pathway, G protein-coupled receptor (GPCR)-mediated integration of enteroendocrine signaling, role of MAPK signaling inhibiting the pathogenesis of influenza, endocannabinoid cancer inhibition pathway, IL-6 signaling, programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) cancer immunotherapy, and extracellular signal-regulated kinase 5 (ERK5) signaling. Here, STAT3 is linked to renal carcinoma.