PTEN and triple-A syndrome: Canonical SGs in AAA had less inflammatory but more neurosignaling, namely, agrin interactions at neuromuscular junction, ErbB signling, cholecystokinin/gastrin-mediated signaling, Her-2 signaling in breast cancer, amyotrophic lateral sclerosis signaling, antioxidant action of vitamin C, PPAR signalin, semaphoring neuronal repulsive signaling, PTEN signaling, and PPARa/RXRa activation.