In addition, atherosclerosis had caspase 4 secretome for inflammation and B cell signaling, namely, roles of NFAT in regulation of immune response, B cell receptor, IL-8 signaling, neuroinflammation, role of PKR in interferon induction and antiviral response, Rac signaling, fMLP signaling, Ephrin receptor, endothelin-1 signaling, and systemic lupus erythematosus in B cell signaling. This evidence concerns the gene CASP4 and systemic lupus erythematosus.