Caspase 1-GSDMD secretomic genes in atherosclerosis had various pathophysiological functions, namely, actin cytoskeleton signaling, leukocyte extravasation signaling, estrogen receptor signaling, actin nucleation by Actin Related Protein 2/3 complex (ARP)-Wiskott–Aldrich syndrome protein (WASP) complex, integrin signaling, synaptogenesis signaling, Rac signaling, Ephrin receptor signaling, and colorectal cancer metastasis signaling. The gene discussed is GSDMD; the disease is atherosclerosis.