ESR1 and Hepatic fibrosis: The pathway analysis indicated that AVF canonical secretome had two functional pathways, namely, pulmonary fibrosis idiopathic signaling and hepatic fibrosis signaling; AVF exosome secretome had 13 functional pathways, namely, signaling by Rho family GTPases, hepatic fibrosis signaling, RHOA signaling, integrin signaling, pulmonary fibrosis idiopathic signaling, regulation of actin-based motility by Rho, IL-8 signaling, CDC42 signaling, EIF2 signaling, actin cytoskeleton signaling, synaptogenesis signaling, estrogen receptor signaling and cardiac hypertrophy signaling (Figure 7C).