Canonical secretomic genes in day 14 AAA aortas had functional pathways, namely, dendritic cell maturation, HMGB1 signaling, IL-6 signaling, neuroprotective role of THOP1 in Alzheimer’s disease, vitamin D receptor (VDR)/RXR activation, cardiac hypertrophy signaling, intrinsic prothrombin activation pathway, synaptogenesis signaling, apelin liver signaling, and GP6 signaling. The gene discussed is HMGB1; the disease is early-onset autosomal dominant Alzheimer disease.