CASP4 and abdominal aortic aneurysm: Taken together, our results have demonstrated that first, among six secretomic pathways in Ang-II induced abdominal aortic aneurysm aortas, canonical, caspase 4, and exosome pathways all have two peak (three-phase) of high (day 7)-low (day 14)-high (day 28) expression patterns; second, caspase 1, WPB and autophagy secretomes are only function at the day 7; and third, the early secretomes may function as drivers for trained immunity (52, 59, 65) and sustained inflammation (51).