Taken together, our results have demonstrated that 1) AVF-venous ECs have significant modulations on the gene expressions of five secretomes but not the expression of autophagy SGs; 2) Upregulations of SGs in AVF-venous ECs result in two pathways in canonical SGs and 13 pathways in exosome SGs; 3) AVF-venous EC SGs have one canonical pathways and five unique exosome pathways; and 4) AVF-venous ECs SGs share two pathways with that of atherosclerotic aorta and CKD aorta; five pathways with MERS-CoV infected ECs, but share no any pathways with that of Ang-II induced AAA. The gene discussed is AGT; the disease is chronic kidney disease.