Exosome SGs at the day 7 AAA aortas had functional pathways, namely, neuroprotective role of THOP1 in Alzheimer’s disease, regulation of actin-based motility by Rho, osteoarthritis pathway, phagosome formation, TREM1 signaling, HIPPO (an evolutionarily conserved serine/threonine kinase) signaling, hepatic fibrosis signaling, role of hypercytokinemia/hyperchemokinemia in pathogenesis of influenza, cell cycle control of chromosomal replication, and EIF2 signaling. Here, THOP1 is linked to early-onset autosomal dominant Alzheimer disease.