ESR1 and colorectal cancer: These results have demonstrated that first, at as early as 6 weeks, atherosclerotic aortas have no functional caspase 1-GSDMD secretomic functions; second, starting from 32 to 78 weeks, atherosclerotic aortas have two major functional pathways, namely, integrin signaling and colorectal cancer metastasis signaling; third, estrogen receptor signaling only appears in 32 weeks atherosclerotic aortas whereas four functional pathways appear only in 78 weeks atherosclerotic aortas, namely, actin nucleation by ARP–WASP complex, synaptogenesis signaling, Rac signaling, and ephrin receptor signaling.