As shown in Figure 2D, the ratios of upregulation versus downregulation of canonical secretome, caspase 1 secretome, caspase 4 secretome, exosome secretome, WPB secretome and autophagy secretome in atherosclerosis, CKD, and AAA were high in atherosclerosis and CKD. The gene discussed is CASP4; the disease is atherosclerosis.