Among caspase 1 SGs upregulated in atherosclerotic aorta (25 genes), CKD aorta (12 genes), AAA aorta (4 genes), MERS-CoV infected ECs (43 genes) and AVF venous EC reprogramming (8 genes), 0 genes were downregulated (LogFC <−1) in NOX2−/− dataset; and 8% (atherosclerotic aorta), 8.33% (CKD aorta), 50% (AAA aorta), 6.98% (MERS-CoV ECs) and 0% genes (AVF venous ECs) (LogFC >1) were upregulated in NRF2−/− dataset, respectively. Here, CASP1 is linked to chronic kidney disease.