Canonical SGs in MERS infection had different metabolic and inflammatory functional pathways, namely, D-myo-inositol 5-phosphate metabolism, 3-phosphoinsitide biosynthesis, thyroid cancer signaling, TREM1 signaling, super pathway of inositol phosphate compounds, bladder cancer signaling, roles of IL-17F in allergic inflammatory airway diseases, IL-23 signaling pathway, FGF signaling, and Th17 activation pathway. The gene discussed is TREM1; the disease is urinary bladder cancer.