Canonical SGs in CKD had inflammatory functional pathways, namely, MIF regulation of innate immunity, TREM1 signaling, crosstalk between dendritic cells and natural killer cells, ILK signaling, neuroinflammation signaling, cardiac hypertrophy, hepatic fibrosis signaling, role of pattern recognition receptors, p38 MAPK signaling, and acute phase response signaling. Here, TREM1 is linked to chronic kidney disease.