For example, as shown in Figure 3A, atherosclerosis had caspase 1 secretome for the functional pathways, namely, actin cytoskeleton signaling, leukocyte extravasation signaling, estrogen receptor signaling, actin nucleation by ARP–WASP complex, integrin signaling, synaptogenesis signaling, Rac signaling, Ephrin receptor signaling and colorectal cancer metastasis signaling. The gene discussed is ESR1; the disease is atherosclerosis.