However, at 32 weeks had three functional pathways, namely, integrin signaling, estrogen receptor signaling, and colorectal cancer metastasis signaling and at 78 weeks atherosclerotic aortas had six functional pathways, namely actin nucleation by ARP–WASP complex, integrin signaling, synaptogenesis signaling, Rac signaling, ephrin receptor signaling, and colorectal cancer metastasis signaling. This evidence concerns the gene ESR1 and colorectal cancer.