Caspase 4 SGs at 6 weeks atherosclerotic aortas had no functional pathways, however, at 32 weeks had functional pathways, namely, ERK/MAPK signaling, IL-8 signaling, neuroinflammation, synaptogenesis, Fc epsilon RI, role of PKR in interferon induction and antiviral response, B cell receptor signaling, endothelin-1 signaling, HOTAIR (a long non-coding RNA) signaling, and systemic lupus erythematosus in B cell signaling. Here, EDN1 is linked to systemic lupus erythematosus.