ACOD1 and triple-A syndrome: As shown in Figure 8D, IRG1 was upregulated in 78 weeks atherosclerotic aorta, 48 h MERS-CoV infected ECs, and IRG1 expression was not significantly increased in MERS-CoV infected ECs at 12, 24, and 36 h post infection and day 7 AAA aorta.