PTEN and early-onset autosomal dominant Alzheimer disease: Exosome SGs at the day 14 AAA aortas had functional pathways, namely, superpathway of cholesterol biosynthesis, PD-1, PD-L1 cancer immunotherapy, intrinsic prothrombin activation, endocannabinoid cancer inhibition pathway, PTEN signaling, role of hypercytokinemia/hyperchemokinemia in pathogenesis of influenza, role of PKR interferon induction and antiviral response, role of p14/p19ARF in tumor suppression, neuroprotective role of THOP1 in Alzheimer’s disease, and RHOGDI signaling.