Caspase 4 SGs at 78 weeks atherosclerotic aortas had functional pathways, namely, role of NFAT in regulation of immune response, B cell receptor signaling, IL-8 signaling, neuroinflammation, role of PKR in interferon induction and antiviral response, Rac (a member of small GTPase family) signaling, formyl peptide receptor 1 (fMLP) signaling in neutrophils, ephrin receptor signaling, endothelin-1 signaling, and systemic lupus erythematosus in B cell signaling. Here, CXCL8 is linked to systemic lupus erythematosus.