Exosome SGs at 32 weeks atherosclerotic aortas had functional pathways, namely, granulocyte–macrophage colony stimulating factor (GM-CSF) signaling, role of NFAT in regulation of immune response, HLA-F-adjacent transcript 10 (FAT10, an ubiquitin-like modifier) cancer signaling, cell cycle control of chromosomal replication, 3-phophoinositide biosynthesis, PDGF signaling, IL-8 signaling, TREM1 signaling, protein kinase Cθ (PKCθ) signaling in T cells, and neuroinflammation signaling. Here, CXCL8 is linked to cancer.