Caspase 4 SGs in elastase induced AAA aortas had functional pathways of amyotrophic lateral sclerosis signaling, Fc epsilon RI signaling, synaptogenesis signaling, fMLP signaling in neutrophils, RAC signaling, Reelin signaling in neurons, IL-8 signaling, endothelin-1 signaling, ephrin receptor signaling, and tumor microenvironment pathway. Here, EDN1 is linked to triple-A syndrome.