Caspase 1-GSDMD SGs in elastase induced AAA aortas had functional pathways, namely, systemic lupus erythematosus in T cell signaling, breast cancer regulation by strathmin1, synaptogenesis signaling, actin nucleation by ARP-WASP complex, RAC signaling, IL-8 signaling, tumor microenvironment pathway, systemic lupus erythematosus in B cell signaling, ephrin receptor signaling, and colorectal cancer metastasis signaling. Here, GSDMD is linked to systemic lupus erythematosus.