These results have demonstrated that CKD modulate canonical SGs for innate immunity and inflammation; caspase 1-GSDMD SGs for senescence and response to wounding; caspase 4-GSDMD SGs for leukocyte extravasation, inflammation, and fibrosis; exosome SGs for MAPK signaling, insulin receptor signaling; Weibel–Palade body SGs for NABA complexes and skeletal system. The gene discussed is INSR; the disease is chronic kidney disease.