To examine this hypothesis, as shown in Figure 2A, we collected microarray and RNA-sequencing data from atherosclerotic apolipoprotein E deficient (ApoE−/−) aorta, CKD accelerated vascular inflammation in rat aorta, MERS-CoV infected human ECs and AAA in patients aortas, deposited in the NIH/NCBI-GeoDatasets database (https://www.ncbi.nlm.nih.gov/gds). Here, APOE is linked to chronic kidney disease.