Canonical secretomic genes in day 28 AAA aortas had functional pathways, namely, acute phase response signaling, inhibition of AU-rich elements (AREs)-mediated mRNA degradation, T cell exhaustion signaling, HOTAIR pathway, tumor microenvironment pathway, IL-17 signaling, systemic lupus erythematosus in B cell signaling, dendritic cell maturation, cardiac hypertrophy signaling, and hepatic fibrosis signaling. Here, HOTAIR is linked to neoplasm.