Caspase 4 SGs at the day 28 AAA aortas had functional pathways, namely, ephrin receptor signaling, type-1 diabetes signaling, role of NFAT in regulation of immune response, phagosome formation, Fcγ receptor-mediated phagocytosis in macrophages and monocytes, IL-15 signaling, p70S6K signaling, leukocyte extravasation signaling, role of PKR in interferon induction and antiviral response, and endothelin-1 signaling. Here, CASP4 is linked to type 1 diabetes mellitus.