Canonical and Caspase 1 Secretome Play Roles at Early MERS-CoV (COVID19 Homologous Virus) Infection Whereas Caspase 4 and Exosome Secretome Play Roles in the Chronic Phase Infection; and the Early Upregulated Canonical and Caspase 1 Secretomes may Function as Drivers for Trained Immunity. The gene discussed is CASP4; the disease is infection.