AGT and triple-A syndrome: As shown in Figure 5C, elastase induced AAA shared six top canonical SG pathways with that of Ang-II induced AAA, namely, tumor microenvironment pathway, TREM1 signaling, role of hypercytokenemia/hyperchemokinemia in the pathogenesis of influenza, systemic lupus erythematosus in B cell signaling, dendritic cell maturation, and IL-17 signaling.