EGFR and amyotrophic lateral sclerosis: As shown in Figure 3C, canonical SGs in AAA aortas had functional pathways, namely, agrin interactions in neuromuscular junction, ErbB signaling, cholecystokinin/gastrin-mediated signaling, HER-2 signaling in breast cancer, amyotrophic lateral sclerosis signaling, antioxidant action of vitamin C, peroxisome proliferators activated receptors (PPAR) signaling, semaphorin neuronal repulsive signaling, phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling and PPARa/RXRa activation.