Canonical secretomic genes at 6-week atherosclerotic aorta had functional pathways, namely, reelin signaling in neurons, role of pattern recognition receptors in recognition of bacteria and viruses, glycoprotein VI (GP6) signaling, estrogen receptor signaling, role of interferon-induced dsRNA-dependent protein kinase (PKR) in interferon induction and antiviral response, factors promoting cardiogenesis, leukocyte extravasation signaling, osteoarthritis pathway, hepatic fibrosis signaling, and acute phase response signaling. The gene discussed is ESR1; the disease is osteoarthritis.