In this study, we detected several common NOD-like receptor and found only NLRP3 gene expression was significantly elevated in DSS-induced colitis model, while NLRP3 gene expression and NLRP3 inflammasome key protein (NLRP3, ASC, cleaved-IL-1β, cleaved-caspase1) were significantly inhibited in colonic tissue of colitis mice and LPS-induced RAW264.7 cells and BMDMs after BAFF blockade. Here, NLRP3 is linked to colitis.