Increasing studies hint BAFF may have an important regulatory role in inflammatory diseases, namely, systemic lupus erythematosus (SLE) (3), primary Sjögrens syndrome (pSS) (4), atherosclerosis (5), chronic obstructive pulmonary disease (COPD) (6), and IBD (7). The gene discussed is TNFSF13B; the disease is irritable bowel syndrome.