Our study confirmed that BAFF blockade significantly inhibited NF-κB pathway proteins (p-IKKα/β/IKKα/β, p-p65/p65, p-IKBα/IKBα)in DSS-induced chronic colitis mouse model and LPS-induced RAW264.7 cells and BMDMs. Here, NFKB1 is linked to Chronic colitis.