Of note, elevated tumor marker CEA (OR 5.25, 95% CI: 1.73-15.93, p=0.003), CA125 (OR 2.79, 95% CI: 1.10-7.11, p=0.031) and NSE (OR 4.86, 95% CI: 1.44-16.37, p=0.011) were both significant independent risk factors for RP-ILD in ASS patients (Figure 2). This evidence concerns the gene ENO2 and neoplasm.