Additionally, while C57BL/6 mice fail to form necrotic granulomas, disseminated infection in C57BL/6 mice deficient for the critical IFN-γ-induced factor iNOS resulted in the formation of sporadic necrotic granulomas that could be enhanced by neutralization of either IFN-γ or TNF (36). This evidence concerns the gene NOS2 and Granuloma.