Functional enrichment analysis revealed 33 FRGs to be primarily involved in vascular fluid dynamics and atherosclerosis, HIF-1a signaling, lipid metabolism, ferroptosis, cysteine and methionine metabolism, glutathione metabolism, amino acid biosynthesis, necroptosis, arachidonic acid metabolism, thyroid hormone synthesis, serotonergic communication, alanine metabolism, aspartate metabolism, glutamate metabolism, inflammatory bowel disease, 2-monocarboxylic acid metabolism, and arginine biosynthesis. This evidence concerns the gene HIF1A and atherosclerosis.