Analysis of gene expression, mutation, DNA methylation, and prognostic value in LUAD revealed CISD1, ATP5MC3, PGD, SLC7A11, ACSL3, and FANCD2 to be significantly upregulated in LUAD and elevated expression of these FRGs to be associated with advanced tumor stage and poor prognosis. The gene discussed is FANCD2; the disease is neoplasm.