Furthermore, KEGG pathway enrichment analysis revealed these FRGs to be primarily involved in vascular fluid dynamics and pathogenesis of atherosclerosis, HIF-1 signaling, lipid metabolism, ferroptosis, amino acid metabolism, necroptosis, thyroid hormone synthesis, serotonergic communication, and inflammatory bowel disease pathogenesis, as well as the metabolism of arachidonic acid, aspartate, alanine, glutamate, and 2-monocarboxylic acid (Figure 2B). Here, HIF1A is linked to atherosclerosis.