Moreover, all the results obtained after administration of the anti-TNF blocking antibody (infliximab) to chronically T. cruzi-infected C57BL/6 mice showing clinical signs of CCC support that TNF contributes to tissue damage, Cx43 loss, and electrical changes as arrhythmias, second-degree atrio-ventricular blockage (AVB-2), and prolongation of the PR and QTc intervals and QRS complex. Here, TNF is linked to cardiac arrhythmia.