Moreover, in addition to LARS, we previously found that mitochondrial LARS2 also possessed the aminoacyl transferase activity required to catalyze K‐Leu.[27] Although LARS2 is located in the mitochondria, identification of the potential roles of LARS2 in regulating TBX5 activity and CHD onset requires further studies. The gene discussed is TBX5; the disease is coronary artery disorder.