LARS1 and coronary artery disorder: For example, leucine can bind to Sestrin2, leading to the activation of mTORC1.[36] Our previous findings have shown that aminoacyl‐tRNA synthetases possess additional aminoacyl transferase activity and can sense the sufficiency of specific amino acids and transmit amino‐acid signals to regulate cellular physiology.[27] In this study, we show that LARS‐associated leucine signaling represented a causal factor for CHD, evident from the increased K‐Leu levels, which increased with elevated leucine concentrations and were correlated with CHD onset.