In a Swedish cohort, the mean age at diagnosis of CHEK2 1100delC carriers was 12 years lower than that of non-carriers (46 vs 58 years, p=0.001) [52] and this has been recently confirmed in an Italian cohort of CHEK2 mutation carriers (median age at first BC onset 46.1 years) [20]. The gene discussed is CHEK2; the disease is breast cancer.