PV/LPVs in MSH2 are correlated with the second highest risk of CRC and the highest risk of developing other non-colorectal cancers, with cumulative cancer incidences at 40 years of 6.9% for CRC in females, 9.9% for CRC in males, and 2.3% for endometrial cancer [72]. The gene discussed is MSH2; the disease is endometrial cancer.