BAP1 mutation carriers showed a lower age at diagnosis in comparison with the general population, and median age of onset associated with null variants was younger than that with missense variants (in null variants: 53 years for uveal melanoma, 55 years for mesothelioma, 39 years for cutaneous melanoma, 50 years for renal tumors, and 44 years for nonmelanoma skin cancer) [106]. This evidence concerns the gene BAP1 and mesothelioma.