BRCA1 and breast cancer: The cumulative BC risk to age 40 years in women was estimated 24% (95%CI, 21–29%) for BRCA1 and 13% (95%CI, 9–19%) for BRCA2 carriers [38], whereas the cumulative BC risk to age 40 in men was 0.12% (95%CI, 0.012–0.58%) for BRCA1 and 1.2% (95%CI, 0.3–3.6%) for BRCA2 carriers [39].