CD8A and neoplasm: There was a significantly higher CD8/Treg ratio in the normal bowel tissue compared with the tumor tissues in both primary and metastatic (P = 0.005 and P = 0.0046, respectively), whereas there was a significantly higher CD4eff/Treg ratio in PBMC compared with the tumor tissue, both primary and metastatic (P = 0.0073 and 0.0255, respectively).