APOB and familial hypercholesterolemia: While the effect on total cholesterol, non-HDL-cholesterol, and apoB is comparable, remarkable differences are seen for triglycerides, LDL-cholesterol and VLDL-cholesterol as well as VLDL-triglycerides indicating a reduction of all apoB containing lipoproteins in FDBL and a predominant reduction of LDL in patients with hypercholesterolemia and mixed hyperlipidemia.