It is noteworthy that in both hypertriglyceridemic patient groups (familial dysbetalipoproteinemia and mixed hyperlipidemia) VLDL-cholesterol is decreased to a larger extent than VLDL-triglycerides, indicating that there might be distinct groups of particles, some of which can be reduced by an increased LDL-receptor activity while others cannot be reduced. The gene discussed is LDLR; the disease is Combined hyperlipidemia.