HAS2 and renal fibrosis: In addition, several of these five genes have been reported to be associated with kidney diseases, for instance, the renal fibrosis and hyaluronic acid (HA) is associated with increased cortical synthesis, human hyaluronic acid synthase 2 (HAS2) transcription induction, and subsequent HAS2-driven HA synthesis may adjust the phenotype of renal proximal renal tubular epithelial cells (PTC) and result in renal fibrosis [21].