The expression profiles of HAS2, MYOF, PLPPR1, QDPR, and SFXN1 genes were extracted from GSE37838, and we found that HAS2 and MYOF expression was upregulated in AKI, and that PLPPR1, QDPR, and SFXN1 genes were significantly downregulated in AKI, which was consistent with our results (Supplementary Figure 1B–1C). Here, PLPPR1 is linked to acute kidney injury.