In CRC, MUTYH (5.77% v 2.28%, OR = 2.62, P = .005 and FDR-P = .027) and ARID1B (1.92% v 6.26%, OR = 0.29, P = .009, and FDR-P = .042) mutational frequencies were significantly different between tumors with KRASG12C versus KRASnon-G12C mutations. Here, ARID1B is linked to colorectal carcinoma.