In CRC, TMB-high status was less frequent in both KRASG12C- and KRASnon-G12C-mutated tumors compared with KRAS-WT tumors (4.40% and 4.70% v 10.34%, OR = 0.3992 and 0.4271, and FDR-P < .0001). Here, KRAS is linked to colorectal carcinoma.