Despite the strong association with smoking, we did not observe a difference in the frequency of TMB-high tumors between KRASG12C-mutant, KRASnon-G12C-mutant, and KRAS-WT NSCLC; in fact, we found a surprisingly lower frequency of TMB-high status in KRASG12C-mutant compared with KRAS-WT CRC. Here, KRAS is linked to colorectal carcinoma.