MUTYH and cancer: For instance, STK11 (20.59% v 5.95%, odds ratio [OR] = 4.10), KEAP1 (15.38% v 4.61%, OR = 3.76), and MUTYH (4.96% v 2.35%, OR = 2.17) were more frequently mutated in KRASG12C-mutant tumors across all cancer types (P < .001 and FDR-P < .01 for all comparisons).