Here, similar to other reports,37,38 we observed a statistically significant association between KRASG12C and MUTYH (5.8% v 2.3%, OR: 2.62 [1.26-5.01]) and between KRASG12C and ARID1B (1.9% v 6.3%, OR: 0.29 [0.08-0.78], compared with KRASnon-G12C-mutant CRC. This evidence concerns the gene ARID1B and colorectal carcinoma.