NF‐κB also contributes to the hypertrophic growth of cardiomyocytes and resultant heart failure.[41] Our findings also suggest that CS‐B‐NO hydrogel treatment efficiently limited the occurrence of cardiomyocyte hypertrophy and myocardial fibrosis after I/R injury, which could be attributed to the inhibition of NF‐κB signaling. Here, NFKB1 is linked to heart failure.