Further, cachexic muscles of the C-26 mouse model displayed increased expression of Bnip3 (Asp et al., 2010; Talbert et al., 2019; Cornwell et al., 2014) and higher autophagic flux (Penna et al., 2013), suggesting that the autophagy–lysosome pathway might also play a role in muscle wasting during cancer-induced cachexia. This evidence concerns the gene BNIP3 and cancer.