In the adult ykiact and RasV12 scrib−/− tumor models, this hyperglycemia is largely due to the systemic reduction of insulin signaling by tumor-derived ImpL2 (Figueroa-Clarevega and Bilder, 2015; Kwon et al., 2015), whereas in the RasV12 scrib−/− larval tumor model, it is a result of systemic autophagy (Khezri et al., 2021). This evidence concerns the gene INS and neoplasm.