Consistent with this, in the adult fly cachexia models, ImpL2 leads to adipose tissue wasting (Figueroa-Clarevega and Bilder, 2015; Kwon et al., 2015), reminiscent of the recent finding that IGFBP2 is a biomarker for cancer cachexia in human pancreatic ductal adenocarcinoma patients (Dong et al., 2021). This evidence concerns the gene IGFBP2 and cancer.