ACE2 and blood coagulation disease: Thus, by reducing ACE2 expression, a phenomenon that occurs afterthe virus binds to the enzyme, there is less conversion of Ang 2 to Ang(1-7) and,consequently, less protective mechanisms and a greater amount of Ang 2, which canworsen the acute lung injury and cause adverse effects on the kidney and heart.Among the symptoms caused by SARS-CoV-2 infection, coagulation disorders,inflammation, and excessive immune response impair the pulmonary, renal, and cardiacphysiology, leading to damage to these organs, possibly due to the involvement ofthe reduction of ACE2 (14).