CXCL8 and infection: Despite having higher PI values than GProb and CG in the same period, the GAtb also showed a lower degree of inflammation, according to PISA values at 90 days; decreased concentrations of IL-8 and IL-1β in GCF, a pro-inflammatory cytokine released by macrophages after an infection or tissue injury;27 and increased concentration of the anti-inflammatory cytokine IL-10.