Rs7943316 ( CAT −21 A/T), for example, is associated with CAT reduced expression21 and reports on the literature focus mainly on conditions such as obesity and vitiligo.21 , 22 For pro-inflammatory cytokines TNF-α and IL-6, SNPs associated with upregulation of gene expression, as well as elevated levels of circulating cytokine, are interesting targets in the context of OM. Here, CAT is linked to obesity due to melanocortin 4 receptor deficiency.