This study sought to investigate the association of rs4880 ( SOD2 47 C/T), rs7943316 ( CAT −21 A/T), rs1800629 ( TNF- α −308 G/A), and rs1800795 ( IL-6 −174 G/C) polymorphisms with the occurrence and severity of OM in children and adolescents with hematological cancers. This evidence concerns the gene IL6 and ocular melanoma.