For the pro-inflammatory cytokines' genes, the GA genotype for rs1800629 ( TNF -α) was more frequent in patients without OM (group I; p=0.03, χ2 test) as well as in patients with a mild case of OM or no OM in the first 60 days of treatment (group III; p=0.0307, χ2 test) when compared with those with severe OM (group IV). The gene discussed is TNF; the disease is ocular melanoma.