Rs7943316 ( CAT −21 A/T), for example, is associated with CAT reduced expression21 and reports on the literature focus mainly on conditions such as obesity and vitiligo.21 , 22 For pro-inflammatory cytokines TNF-α and IL-6, SNPs associated with upregulation of gene expression, as well as elevated levels of circulating cytokine, are interesting targets in the context of OM. Here, TNF is linked to ocular melanoma.