CD274 and neoplasm: PFS wasslightly increased in patients with an interval longer than 5 years from thediagnosis of the primary tumor to metastases and in those with extrahepaticmetastases(14).Differences in oncogenic mutations, PD1/PD-L1 patterns of expression, and a numberof tumor-infiltrating lymphocytes have been proposed as key factors for responsevariability toward ICI in uveal melanoma(15).