LEP and obesity due to melanocortin 4 receptor deficiency: Obesity is defined as potentially health-damaging abnormal or excessive fatdeposition in adipose tissue(11).Obesity causes increased lipid accumulation in adipose tissue, increased release ofpro-inflammatory adipocytokines, such as resistin, leptin, interleukin-6, and tumornecrosis factor, and decreased secretion of anti-inflammatory cytokines, such asadiponectin(12,13).