Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. The gene discussed is ACE; the disease is myocardial infarction.