Given that GH replacement has not been shown to influence tumour progression (recurrence and/or growth) of pituitary adenomas or craniopharyngioma in adults, an individualized shared decision should be made regarding the resumption of GH therapy based on factors such as the underlying diagnosis, degree of tumour progression, and the extent of the intervention that was required to achieve relapse (68). Here, GH1 is linked to pituitary gland adenoma.