GH1 and hypopituitarism: The decision to test for GHD and replace GH in children and adults who have survived cancer and those with a high genetic susceptibility to develop cancer can be challenging and should only be considered if these patients had a suggestive history of possible GHD such as structural hypothalamic/pituitary disease, surgery or irradiation in these areas, head trauma, or evidence of other pituitary hormone deficiencies, in line with previous clinical practice guidelines (3).