PML and neoplasm: Several further reports on the formation of enlarged PML-NBs can be found in literature, for instance as alternative lengthening of telomers (ALT)-associated PML-NBs in telomerase-negative tumor cells, in cells quiescently infected with HSV-1, and during infection with BK virus or Merkel cell polyomavirus (Everett et al., 2007; Jiang et al., 2011; Yeager et al., 1999; Neumann et al., 2016).