This study also showed significant reductions in both bronchoalveolar lavage fluid (BALF) and serum concentrations of IL-6 and ICAM-1, enhanced SOD expression and a reduction in myeloperoxidase activity and NF-κB signaling, highlighting a potential role for curcumin in the treatment of not only CVD but also in the modulation of chronic lung disease such as COPD. This evidence concerns the gene NFKB1 and chronic obstructive pulmonary disease.