To further elucidate the potential regulatory role of YTHDF1 in breast cancer, we genetically depleted YTHDF1 in breast cancer cells and systematically monitored the phenotypical changes after the transfection of two YTHDF1-targeting siRNAs (siYTHDF1 1 and siYTHDF1 2). The gene discussed is YTHDF1; the disease is breast cancer.