INS and Insulin resistance: Furthermore, the observed reduction in hepatic triacylglycerol and enhanced insulin tolerance contrast with the hepatic steatosis and insulin resistance that occur in models of tissue-specific glucocorticoid excess (5αR1 deletion and hepatic 11βHSD1 overexpression) (Paterson et al. 2004, Dowman et al. 2013, Livingstone et al. 2015).