We used generalized estimating equations to examine longitudinal associations between recent (past 6‐month) sex work with three types of outcomes: psychosocial (recent violence, recent injection drug use, hazardous alcohol use, clinical depression and post‐traumatic stress disorder), clinical HIV (CD4 count and viral load) and stigma (HIV‐related stigma, racial discrimination and gender discrimination). This evidence concerns the gene CD4 and depressive disorder.