Another recent study found that BCAT1 was able to activate PI3K/Akt/mTOR signalling pathway, contributing to the angiogenesis and tumorigenicity of gastric cancer cells,28 although we did not observe repression of Akt phosphorylation by knockdown of BCAT1 in SCLC cells (Figure 5E). The gene discussed is MTOR; the disease is small cell lung carcinoma.