CD274 and cancer: Human leucocyte antigen class I molecules (HLA‐I) display short peptides, typically 9–11 amino acids in length, primarily derived from the cellular proteome, to CD8+ T cells which permits the detection of intracellular pathogens such as viruses, and also up‐regulated or mutated proteins relevant in cancer [1] However, a key problem in the context of cancer cells is their ability to evade elimination by cytotoxic CD8+ T cells through the expression of immune checkpoint proteins such as PD‐L1.