Our findings demonstrated that dmVMH burst firing neurons play an important role in connecting the emotional state of anxiety and energy homeostasis, Cav 3.1 is essential for burst firing in dmVMH, and knockdown of Cav3.1 or administration of fluoxetine rescued anxiety-related energy expenditure changes through inhibition of burst firing in dmVMH (Fig. 6i). This evidence concerns the gene CACNA1G and Anxiety.