ALKBH5 and lung carcinoma: We further analyzed the protein expression of YTHDF2 in lung cancer cell lines (Fig. 8D) and conducted transfection of siRNA for YTHDF2 as previously described [59], which confirmed that upregulated expression of CDKN1A by ALKBH5 knockdown was increased by YTHDF2 knockdown in PC9, which suggested that m6A of CDKN1A may be affected by both IGF2BPs and YTHDF2 reversibly (Fig. 8E and S8F).