Other genes significantly increased in VIVA1 cells with known links to metastasis included HMGCS2, which increased tumour cell invasion and metastasis in oral and colorectal cancer [63] as well as breast cancer cell lines [64], and SNCG which has also been shown to increase breast cancer cell invasion and metastasis when overexpressed [65, 66]. This evidence concerns the gene HMGCS2 and colorectal cancer.