ADCY1 and neoplasm: Although their specific role in ILC metastasis in our model remains to be examined, it is interesting to note that some of these targets such as ADCY1, which was decreased in VIVA1 compared to parental cells, have been recently shown to be decreased in association with increased metastasis in other tumour types [69, 70], and PLCB2 which was increased in VIVA1 cells has been associated with worse overall survival in lung cancer [71].