When classified according to the type of ILD, baseline LDH and relative changes in KL-6 levels over 1 week were significantly associated with in-hospital mortality in patients with AE-IPF in the unadjusted logistic regression analysis (Supplementary Table S2); however, baseline CRP and changes in CRP levels over 1 were significant prognostic factors in those with AE-non IPF (Supplementary Table S3). This evidence concerns the gene CRP and idiopathic interstitial pneumonia.