The overexpression of FcRL5 on IgG+ T-bethi atypical MBCs in vivax malaria might be part of a feedback mechanism which downregulates the hyperactivated state of atypical MBCs, or they may be markers of durable and robust responses to re-infection as previously proposed in P. falciparum studies36. The gene discussed is FCRL5; the disease is Plasmodium vivax malaria.