Mice with a conventional knockout of Gabrb3 in all cell types, exhibit a variety of behavioral abnormalities, such as impaired sociability, epilepsy, stereotypical behavior, poor motor skills on a repetitive task, hyperactivity, altered gamma network oscillations, learning and memory deficits, and disturbed rest-activity cycle (Table 1); phenotypic traits that were linked to autism spectrum disorder and Angelman syndrome49,50. The gene discussed is GABRB3; the disease is epilepsy.