The renal accumulations of monocytes, B and T cells, anti-glomerular antibodies, elevated IL-12 and IFNγ cytokines, and various glomerular pathologies in Clr-f−/− mice closely resemble the autoimmune landscape of the LN mouse models (ie, MRL-Faslpr)35–37. This evidence concerns the gene IFNG and lobular neoplasia.