Moreover, in cancer, where there is an emerging body of evidence for a pathogenic role for LRG114,18, the induction of LRG1 in tumour endothelial cells has also been shown to contribute to pathological neovascularisation19 and priming the vascular metastatic niche20 establishing this secreted glycoprotein as a new vasculopathic molecule. The gene discussed is LRG1; the disease is cancer.