Since tumor penetrance was only 18% in this constitutive heterozygous Sox2-cre model (Supplementary Table 1) and a vulnerable time window of RT induction has already been described for ubiquitously inducible Smarcb1 knockout models and for Smarcb1 loss in neural crest cells16,18, we next assessed the susceptibility of tumor initiation in an inducible Sox2-cre system (further referred to as Sox2-creERT2). Here, SOX2 is linked to neoplasm.