MYC and melanoma: While showing a low mutational burden, RT are characterized by a molecular heterogeneity which includes 5 stable methylation subgroups: the three pre-known ATRT-SHH (activated sonic hedgehog signaling), ATRT-MYC (MYC oncogene-driven), and ATRT-TYR (active melanoma-associated genes)7, as well as two novel groups, group 3 and group 411,12.