Strikingly, we obtained mid/hindbrain progenitor cells as most similar embryonic cell type for ATRT-SHH tumor cells, whereas primordial germ cells (PGCs) emerged as the cell type with the highest similarity score for ATRT-MYC (MYC IC-RT and MYC spinal tumors) and eRT (Fig. 4A, Supplementary Fig. 8). This evidence concerns the gene SHH and neoplasm.