Whereas neither Nestin-cre::Smarcb1fl/+ nor Olig1-cre::Smarcb1fl/+ mouse strains showed any pathological phenotype (Supplementary Fig. 1Ba, Ca’, Supplementary Table 1), hGFAP-cre::Smarcb1fl/+ and Math1-cre::Smarcb1fl/+ mice gave rise to different tumor entities with a tumor penetrance of 11% and 4%, respectively. The gene discussed is OLIG1; the disease is neoplasm.