In attempt to explore the role of MYH9 in growth and metastasis of RCC cells, we silenced the expression of MYH9 with shRNA and overexpressed MYH9 with lentivirus-MYH9 (LV-MYH9) in two ccRCC cell lines (Figs. 3a, b and 4a, b). The gene discussed is MYH9; the disease is nonpapillary renal cell carcinoma.