EGFR is abundantly expressed on the surface of multiple kinds of solid tumors, including head and neck squamous cell carcinomas (HNSCC), esophageal cancer, lung cancer, colon cancer, pancreatic cancer and other solid tumors.225 Cetuximab sarotalocan could target EGFR and be activated locally by the red laser released by the optical fiber after targeted combination with cancer cells, resulting in the cell death. The gene discussed is EGFR; the disease is colonic neoplasm.