ERBB2 and interstitial lung disease: Moreover, the immune response induced by the antibody part of ADC may cause secondary injuries, resulting in nephrotoxicity.256 According to the recent clinical observations, the potential lung toxic effects like ILD during ADC treatment period should arouse attention, particularly in anti-HER2 ADCs.257,258 Several death cases have been reported to be related with ILD during the clinical trials of T-DM1 and DS-8201.257,258 The detailed mechanism of action of ILD, however, remain unclear.