Previous studies on ferroptosis in the CNS mostly focused on neurons [39, 40] until a recent study using human and mouse Pelizaeus-Merzbacher disease (PMD) oligodendrocytes, demonstrated that PLP1 gene mutation caused severe iron sensitivity and the cell death involved various cell pathogenetic mechanisms of iron-induced ferroptosis, ER stress and apoptosis, and these pathways in some PMD lines are alleviated by iron chelation [41]. This evidence concerns the gene PLP1 and Pelizeaus-Merzbacher spectrum disorder.