Compared to the sh-UPF1-NC + sh-LINC00963-NC group, inhibition of UPF1, inhibition of LINC00963, or inhibition of UPF1 combined with inhibition of LINC00963 significantly reduced the expression of SOX2, OCT4, and NANOG (Fig. 5B), impaired tumor sphere formation (Fig. 5C), increased the cytotoxic effect of carboplatin (Fig. 5D, E), attenuated cell proliferation (Fig. 5F), impeded cell migration and invasion (Fig. 5G), promoted apoptosis (Fig. 5H), and decreased the cell numbers in G2–M phase of the cell cycle (Fig. 5I). This evidence concerns the gene SOX2 and neoplasm.