Conversely, knockdown of GIT1 expression by two different shRNAs accelerated tumour formation and growth in the xenografted animals (Fig. 5a, c; MDA-MB-231 xenograft tumours, Ctrl-shRNA (n = 13) versus GIT1-shRNA2 (n = 15), P = 0.12, log-rank test, P = 0.0063, Mann–Whitney U-test). The gene discussed is GIT1; the disease is neoplasm.