Moreover, we previously found prominent accumulation of tau pathology in juxtacortical white matter (WM) in FTLD-Tau that is relatively distinct from FTLD-TDP across clinical syndromes and proteinopathy subtypes (McMillan et al., 2012; Irwin et al., 2018; Giannini et al., 2021). This evidence concerns the gene MAPT and proteostasis deficiencies.