MAPT and proteostasis deficiencies: Next, we performed cross-validation sensitivity analyses where we repeated the FTLD-Tau and FTLD-TDP GM+WM histopathology network comparisons while excluding each main proteinopathy subgroup; we found similar results of overall greater correlation of GM-WM node pairs (i.e., greater number of significant GM-WM edges) in each FTLD-Tau versus FTLD-TDP subgroup comparison (Fig. 4).