Delightedly, oral intake of calcitriol reduced PD-1, TIGIT and Tim-3 levels and increased CD28 expression on CD8+ and Vγ9Vδ2+ T cells compared with a single dose of docetaxel treatment in patients with NSCLC (figure 1E-P and online supplemental figure S6A–D). The gene discussed is CD28; the disease is non-small cell lung carcinoma.